MovDisordV3, Main, Exploration, bibRecord, 000F85

Short Latency Activation of Cortex During Clinically Effective Subthalamic Deep Brain Stimulation for Parkinson's Disease

Identifieur interne : 000F85 ( Main/Exploration ); précédent : 000F84; suivant : 000F86

Short Latency Activation of Cortex During Clinically Effective Subthalamic Deep Brain Stimulation for Parkinson's Disease

Auteurs : Harrison C. Walker [États-Unis] ; HE HUANG [États-Unis] ; Christopher L. Gonzalez [États-Unis] ; James E. Bryant [États-Unis] ; Jeffrey Killen [États-Unis] ; Gary R. Cutter [États-Unis] ; Robert C. Knowlton [États-Unis] ; Erwin B. Montgomery [États-Unis] ; Bart L. Guthrie [États-Unis] ; Ray L. Watts [États-Unis]

Source :

Movement disorders [ 0885-3185 ] ; 2012.

RBID : Pascal:12-0280031

Descripteurs français

Pascal (Inist)
- Cortex cérébral, Encéphale, Maladie de Parkinson, Noyau ventral, Pathologie du système nerveux, Noyau sousthalamique, Potentiel évoqué cognitif, Electroencéphalographie, Stimulation cérébrale profonde, Thalamus, Tremblement.

English descriptors

KwdEn :
- Aged, Analysis of Variance, Biophysics, Brain Mapping, Cerebral Cortex (physiopathology), Cerebral cortex, Deep Brain Stimulation (methods), Deep brain stimulation, Electroencephalography, Encephalon, Event evoked potential, Evoked Potentials (physiology), Female, Humans, Male, Middle Aged, Motor Activity (physiology), Nervous system diseases, Nonlinear Dynamics, Parkinson Disease (pathology), Parkinson Disease (therapy), Parkinson disease, Reaction Time (physiology), Regression Analysis, Subthalamic nucleus, Subthalamus (physiology), Thalamus, Thalamus (physiology), Time Factors, Tremor, Tremor (pathology), Tremor (therapy), Ventral nucleus.
MESH :
- methods : Deep Brain Stimulation.
- pathology : Parkinson Disease, Tremor.
- physiology : Evoked Potentials, Motor Activity, Reaction Time, Subthalamus, Thalamus.
- physiopathology : Cerebral Cortex.
- therapy : Parkinson Disease, Tremor.
- Aged, Analysis of Variance, Biophysics, Brain Mapping, Electroencephalography, Female, Humans, Male, Middle Aged, Nonlinear Dynamics, Regression Analysis, Time Factors.

Abstract

Subthalamic deep brain stimulation (DBS) is superior to medical therapy for the motor symptoms of advanced Parkinson's disease (PD), and additional evidence suggests that it improves refractory symptoms of essential tremor, primary generalized dystonia, and obsessive-compulsive disorder. Despite this, its therapeutic mechanism is unknown. We hypothesized that subthalamic stimulation activates the cerebral cortex at short latencies after stimulus onset during clinically effective stimulation for PD. In 5 subjects (six hemispheres), EEG measured the response of cortex to subthalamic stimulation across a range of stimulation voltages and frequencies. Novel analytical techniques reversed the anode and cathode electrode contacts and summed the resulting pair of event-related potentials to suppress the stimulation artifact. We found that subthalamic brain stimulation at 20 Hz activates the somatosensory cortex at discrete latencies (mean latencies: 1.0 ± 0.4, 5.7 ±1.1, and 22.2 ± 1.8 ms, denoted as R1, R2, and R3, respectively). The amplitude of the short latency peak (R1) during clinically effective high-frequency stimulation is nonlinearly dependent on stimulation voltage (P < 0.001; repeated-measures analysis of variance), and its latency is less variable than that of R3 (1.02 versus 19.46 ms; P < 0.001, Levene's test). We conclude that clinically effective subthalamic brain stimulation in humans with PD activates the cerebral cortex at 1 ms after stimulus onset, most likely by antidromic activation. These findings suggest that alteration of the precise timing of action potentials in cortical neurons with axonal projections to the subthalamic region may be an important component of the therapeutic mechanism of subthalamic brain stimulation.

Url:

Affiliations:

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Short Latency Activation of Cortex During Clinically Effective Subthalamic Deep Brain Stimulation for Parkinson's Disease</title>
<author><name sortKey="Walker, Harrison C" sort="Walker, Harrison C" uniqKey="Walker H" first="Harrison C." last="Walker">Harrison C. Walker</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, University of Alabama at Birmingham</s1>
<s2>Birmingham, Alabama</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Alabama</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Biomedical Engineering, University of Alabama at Birmingham</s1>
<s2>Birmingham, Alabama</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Alabama</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="He Huang" sort="He Huang" uniqKey="He Huang" last="He Huang">HE HUANG</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, University of Alabama at Birmingham</s1>
<s2>Birmingham, Alabama</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Alabama</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gonzalez, Christopher L" sort="Gonzalez, Christopher L" uniqKey="Gonzalez C" first="Christopher L." last="Gonzalez">Christopher L. Gonzalez</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, University of Alabama at Birmingham</s1>
<s2>Birmingham, Alabama</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Alabama</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bryant, James E" sort="Bryant, James E" uniqKey="Bryant J" first="James E." last="Bryant">James E. Bryant</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, University of Alabama at Birmingham</s1>
<s2>Birmingham, Alabama</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Alabama</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Killen, Jeffrey" sort="Killen, Jeffrey" uniqKey="Killen J" first="Jeffrey" last="Killen">Jeffrey Killen</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, University of Alabama at Birmingham</s1>
<s2>Birmingham, Alabama</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Alabama</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cutter, Gary R" sort="Cutter, Gary R" uniqKey="Cutter G" first="Gary R." last="Cutter">Gary R. Cutter</name>
<affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Department of Biostatistics, University of Alabama at Birmingham</s1>
<s2>Birmingham, Alabama</s2>
<s3>USA</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Alabama</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Knowlton, Robert C" sort="Knowlton, Robert C" uniqKey="Knowlton R" first="Robert C." last="Knowlton">Robert C. Knowlton</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, University of Alabama at Birmingham</s1>
<s2>Birmingham, Alabama</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Alabama</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Montgomery, Erwin B" sort="Montgomery, Erwin B" uniqKey="Montgomery E" first="Erwin B." last="Montgomery">Erwin B. Montgomery</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, University of Alabama at Birmingham</s1>
<s2>Birmingham, Alabama</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Alabama</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Biomedical Engineering, University of Alabama at Birmingham</s1>
<s2>Birmingham, Alabama</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Alabama</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Guthrie, Bart L" sort="Guthrie, Bart L" uniqKey="Guthrie B" first="Bart L." last="Guthrie">Bart L. Guthrie</name>
<affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Department of Surgery, Division of Neurosurgery, University of Alabama at Birmingham</s1>
<s2>Birmingham, Alabama</s2>
<s3>USA</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Alabama</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Watts, Ray L" sort="Watts, Ray L" uniqKey="Watts R" first="Ray L." last="Watts">Ray L. Watts</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, University of Alabama at Birmingham</s1>
<s2>Birmingham, Alabama</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Alabama</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">12-0280031</idno>
<date when="2012">2012</date>
<idno type="stanalyst">PASCAL 12-0280031 INIST</idno>
<idno type="RBID">Pascal:12-0280031</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000162</idno>
<idno type="wicri:Area/PascalFrancis/Curation">002B52</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000058</idno>
<idno type="wicri:doubleKey">0885-3185:2012:Walker H:short:latency:activation</idno>
<idno type="wicri:Area/Main/Merge">001037</idno>
<idno type="wicri:source">INIST</idno>
<idno type="RBID">Pascal:12-0393081</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000077</idno>
<idno type="wicri:Area/PascalFrancis/Curation">002C37</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000057</idno>
<idno type="wicri:doubleKey">0885-3185:2012:Walker H:short:latency:activation</idno>
<idno type="wicri:Area/Main/Merge">001036</idno>
<idno type="wicri:source">PMC</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691999</idno>
<idno type="RBID">PMC:3691999</idno>
<idno type="wicri:Area/Pmc/Corpus">000282</idno>
<idno type="wicri:Area/Pmc/Curation">000282</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000159</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="wicri:Area/PubMed/Corpus">000C71</idno>
<idno type="wicri:Area/PubMed/Curation">000C71</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000C33</idno>
<idno type="wicri:Area/Ncbi/Merge">003775</idno>
<idno type="wicri:Area/Ncbi/Curation">003775</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">003775</idno>
<idno type="wicri:doubleKey">0885-3185:2012:Walker H:short:latency:activation</idno>
<idno type="wicri:Area/Main/Merge">000C26</idno>
<idno type="wicri:source">PMC</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636546</idno>
<idno type="RBID">PMC:3636546</idno>
<idno type="wicri:Area/Pmc/Corpus">000265</idno>
<idno type="wicri:Area/Pmc/Curation">000265</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000158</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="wicri:Area/PubMed/Corpus">000D69</idno>
<idno type="wicri:Area/PubMed/Curation">000D69</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000C32</idno>
<idno type="wicri:Area/Ncbi/Merge">003677</idno>
<idno type="wicri:Area/Ncbi/Curation">003677</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">003677</idno>
<idno type="wicri:doubleKey">0885-3185:2012:Walker H:short:latency:activation</idno>
<idno type="wicri:Area/Main/Merge">000C25</idno>
<idno type="wicri:Area/Main/Curation">000F85</idno>
<idno type="wicri:Area/Main/Exploration">000F85</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Short Latency Activation of Cortex During Clinically Effective Subthalamic Deep Brain Stimulation for Parkinson's Disease</title>
<author><name sortKey="Walker, Harrison C" sort="Walker, Harrison C" uniqKey="Walker H" first="Harrison C." last="Walker">Harrison C. Walker</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, University of Alabama at Birmingham</s1>
<s2>Birmingham, Alabama</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Alabama</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Biomedical Engineering, University of Alabama at Birmingham</s1>
<s2>Birmingham, Alabama</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Alabama</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="He Huang" sort="He Huang" uniqKey="He Huang" last="He Huang">HE HUANG</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, University of Alabama at Birmingham</s1>
<s2>Birmingham, Alabama</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Alabama</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gonzalez, Christopher L" sort="Gonzalez, Christopher L" uniqKey="Gonzalez C" first="Christopher L." last="Gonzalez">Christopher L. Gonzalez</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, University of Alabama at Birmingham</s1>
<s2>Birmingham, Alabama</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Alabama</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bryant, James E" sort="Bryant, James E" uniqKey="Bryant J" first="James E." last="Bryant">James E. Bryant</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, University of Alabama at Birmingham</s1>
<s2>Birmingham, Alabama</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Alabama</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Killen, Jeffrey" sort="Killen, Jeffrey" uniqKey="Killen J" first="Jeffrey" last="Killen">Jeffrey Killen</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, University of Alabama at Birmingham</s1>
<s2>Birmingham, Alabama</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Alabama</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cutter, Gary R" sort="Cutter, Gary R" uniqKey="Cutter G" first="Gary R." last="Cutter">Gary R. Cutter</name>
<affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Department of Biostatistics, University of Alabama at Birmingham</s1>
<s2>Birmingham, Alabama</s2>
<s3>USA</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Alabama</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Knowlton, Robert C" sort="Knowlton, Robert C" uniqKey="Knowlton R" first="Robert C." last="Knowlton">Robert C. Knowlton</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, University of Alabama at Birmingham</s1>
<s2>Birmingham, Alabama</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Alabama</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Montgomery, Erwin B" sort="Montgomery, Erwin B" uniqKey="Montgomery E" first="Erwin B." last="Montgomery">Erwin B. Montgomery</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, University of Alabama at Birmingham</s1>
<s2>Birmingham, Alabama</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Alabama</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Biomedical Engineering, University of Alabama at Birmingham</s1>
<s2>Birmingham, Alabama</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Alabama</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Guthrie, Bart L" sort="Guthrie, Bart L" uniqKey="Guthrie B" first="Bart L." last="Guthrie">Bart L. Guthrie</name>
<affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Department of Surgery, Division of Neurosurgery, University of Alabama at Birmingham</s1>
<s2>Birmingham, Alabama</s2>
<s3>USA</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Alabama</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Watts, Ray L" sort="Watts, Ray L" uniqKey="Watts R" first="Ray L." last="Watts">Ray L. Watts</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, University of Alabama at Birmingham</s1>
<s2>Birmingham, Alabama</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Alabama</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Analysis of Variance</term>
<term>Biophysics</term>
<term>Brain Mapping</term>
<term>Cerebral Cortex (physiopathology)</term>
<term>Cerebral cortex</term>
<term>Deep Brain Stimulation (methods)</term>
<term>Deep brain stimulation</term>
<term>Electroencephalography</term>
<term>Encephalon</term>
<term>Event evoked potential</term>
<term>Evoked Potentials (physiology)</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Motor Activity (physiology)</term>
<term>Nervous system diseases</term>
<term>Nonlinear Dynamics</term>
<term>Parkinson Disease (pathology)</term>
<term>Parkinson Disease (therapy)</term>
<term>Parkinson disease</term>
<term>Reaction Time (physiology)</term>
<term>Regression Analysis</term>
<term>Subthalamic nucleus</term>
<term>Subthalamus (physiology)</term>
<term>Thalamus</term>
<term>Thalamus (physiology)</term>
<term>Time Factors</term>
<term>Tremor</term>
<term>Tremor (pathology)</term>
<term>Tremor (therapy)</term>
<term>Ventral nucleus</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Deep Brain Stimulation</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Parkinson Disease</term>
<term>Tremor</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Evoked Potentials</term>
<term>Motor Activity</term>
<term>Reaction Time</term>
<term>Subthalamus</term>
<term>Thalamus</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Cerebral Cortex</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term>
<term>Tremor</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Analysis of Variance</term>
<term>Biophysics</term>
<term>Brain Mapping</term>
<term>Electroencephalography</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Nonlinear Dynamics</term>
<term>Regression Analysis</term>
<term>Time Factors</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Cortex cérébral</term>
<term>Encéphale</term>
<term>Maladie de Parkinson</term>
<term>Noyau ventral</term>
<term>Pathologie du   système nerveux</term>
<term>Noyau sousthalamique</term>
<term>Potentiel évoqué cognitif</term>
<term>Electroencéphalographie</term>
<term>Stimulation cérébrale profonde</term>
<term>Thalamus</term>
<term>Tremblement</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Subthalamic deep brain stimulation (DBS) is superior to medical therapy for the motor symptoms of advanced Parkinson's disease (PD), and additional evidence suggests that it improves refractory symptoms of essential tremor, primary generalized dystonia, and obsessive-compulsive disorder. Despite this, its therapeutic mechanism is unknown. We hypothesized that subthalamic stimulation activates the cerebral cortex at short latencies after stimulus onset during clinically effective stimulation for PD. In 5 subjects (six hemispheres), EEG measured the response of cortex to subthalamic stimulation across a range of stimulation voltages and frequencies. Novel analytical techniques reversed the anode and cathode electrode contacts and summed the resulting pair of event-related potentials to suppress the stimulation artifact. We found that subthalamic brain stimulation at 20 Hz activates the somatosensory cortex at discrete latencies (mean latencies: 1.0 ± 0.4, 5.7 ±1.1, and 22.2 ± 1.8 ms, denoted as R1, R2, and R3, respectively). The amplitude of the short latency peak (R1) during clinically effective high-frequency stimulation is nonlinearly dependent on stimulation voltage (P < 0.001; repeated-measures analysis of variance), and its latency is less variable than that of R3 (1.02 versus 19.46 ms; P < 0.001, Levene's test). We conclude that clinically effective subthalamic brain stimulation in humans with PD activates the cerebral cortex at 1 ms after stimulus onset, most likely by antidromic activation. These findings suggest that alteration of the precise timing of action potentials in cortical neurons with axonal projections to the subthalamic region may be an important component of the therapeutic mechanism of subthalamic brain stimulation.</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Alabama</li>
</region>
</list>
<tree><country name="États-Unis"><region name="Alabama"><name sortKey="Walker, Harrison C" sort="Walker, Harrison C" uniqKey="Walker H" first="Harrison C." last="Walker">Harrison C. Walker</name>
</region>
<name sortKey="Bryant, James E" sort="Bryant, James E" uniqKey="Bryant J" first="James E." last="Bryant">James E. Bryant</name>
<name sortKey="Cutter, Gary R" sort="Cutter, Gary R" uniqKey="Cutter G" first="Gary R." last="Cutter">Gary R. Cutter</name>
<name sortKey="Gonzalez, Christopher L" sort="Gonzalez, Christopher L" uniqKey="Gonzalez C" first="Christopher L." last="Gonzalez">Christopher L. Gonzalez</name>
<name sortKey="Guthrie, Bart L" sort="Guthrie, Bart L" uniqKey="Guthrie B" first="Bart L." last="Guthrie">Bart L. Guthrie</name>
<name sortKey="He Huang" sort="He Huang" uniqKey="He Huang" last="He Huang">HE HUANG</name>
<name sortKey="Killen, Jeffrey" sort="Killen, Jeffrey" uniqKey="Killen J" first="Jeffrey" last="Killen">Jeffrey Killen</name>
<name sortKey="Knowlton, Robert C" sort="Knowlton, Robert C" uniqKey="Knowlton R" first="Robert C." last="Knowlton">Robert C. Knowlton</name>
<name sortKey="Montgomery, Erwin B" sort="Montgomery, Erwin B" uniqKey="Montgomery E" first="Erwin B." last="Montgomery">Erwin B. Montgomery</name>
<name sortKey="Montgomery, Erwin B" sort="Montgomery, Erwin B" uniqKey="Montgomery E" first="Erwin B." last="Montgomery">Erwin B. Montgomery</name>
<name sortKey="Walker, Harrison C" sort="Walker, Harrison C" uniqKey="Walker H" first="Harrison C." last="Walker">Harrison C. Walker</name>
<name sortKey="Watts, Ray L" sort="Watts, Ray L" uniqKey="Watts R" first="Ray L." last="Watts">Ray L. Watts</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000F85 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000F85 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Santé
   |area=    MovDisordV3
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     Pascal:12-0280031
   |texte=   Short Latency Activation of Cortex During Clinically Effective Subthalamic Deep Brain Stimulation for Parkinson's Disease
}}

This area was generated with Dilib version V0.6.23.
Data generation: Sun Jul 3 12:29:32 2016. Site generation: Wed Feb 14 10:52:30 2024

Movement Disorders (revue)

Short Latency Activation of Cortex During Clinically Effective Subthalamic Deep Brain Stimulation for Parkinson's Disease

Short Latency Activation of Cortex During Clinically Effective Subthalamic Deep Brain Stimulation for Parkinson's Disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.